Cargando…

Antiproliferative S-Trityl-l-Cysteine -Derived Compounds as SIRT2 Inhibitors: Repurposing and Solubility Enhancement

S-trityl-l-cysteine (STLC) is a well-recognized lead compound known for its anticancer activity owing to its potent inhibitory effect on human mitotic kinesin Eg5. STLC contains two free terminal amino and carboxyl groups that play pivotal roles in binding to the Eg5 pocket. On the other hand, such...

Descripción completa

Detalles Bibliográficos
Autores principales:	Radwan, Mohamed O., Ciftci, Halil I., Ali, Taha F. S., Ellakwa, Doha E., Koga, Ryoko, Tateishi, Hiroshi, Nakata, Akiko, Ito, Akihiro, Yoshida, Minoru, Okamoto, Yoshinari, Fujita, Mikako, Otsuka, Masami
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6766826/ https://www.ncbi.nlm.nih.gov/pubmed/31510043 http://dx.doi.org/10.3390/molecules24183295

Ejemplares similares

In Vitro and In Silico Evaluation of Anticancer Activity of New Indole-Based 1,3,4-Oxadiazoles as EGFR and COX-2 Inhibitors
por: Sever, Belgin, et al.
Publicado: (2020)

Introduction of H2C2‐type zinc‐binding residues into HIV‐2 Vpr increases its expression level
por: Koga, Ryoko, et al.
Publicado: (2017)

Design, Synthesis and Biological Evaluation of Pentacyclic Triterpene Derivatives: Optimization of Anti-ABL Kinase Activity
por: I. Ciftci, Halil, et al.
Publicado: (2019)

In-Cell Trityl–Trityl Distance Measurements on Proteins
por: Yang, Yin, et al.
Publicado: (2020)

Design, Synthesis, and Biological Evaluation of Novel 1,3,4-Thiadiazole Derivatives as Potential Antitumor Agents against Chronic Myelogenous Leukemia: Striking Effect of Nitrothiazole Moiety
por: Altıntop, Mehlika Dilek, et al.
Publicado: (2017)

Synthesis and Evaluation of New Pyrazoline Derivatives as Potential Anticancer Agents
por: Karabacak, Muhammed, et al.
Publicado: (2015)

Discovery of Azaindolin-2-One as a Dual Inhibitor of GSK3β and Tau Aggregation with Potential Neuroprotective Activity
por: Ali, Taha F. S., et al.
Publicado: (2022)

A clue to unprecedented strategy to HIV eradication: “Lock-in and apoptosis”
por: Tateishi, Hiroshi, et al.
Publicado: (2017)

Antileukemic Activity of Twig Components of Caucasian Beech in Turkey
por: Shida, Wataru, et al.
Publicado: (2019)

Serial Femtosecond X-Ray Diffraction of HIV-1 Gag MA-IP6 Microcrystals at Ambient Temperature
por: I Ciftci, Halil, et al.
Publicado: (2019)

Structural Characterization of TRAF6 N-Terminal for Therapeutic Uses and Computational Studies on New Derivatives
por: Guven, Omur, et al.
Publicado: (2023)

N-Trityl-2-(tritylsulfanyl)aniline
por: Neuba, Adam, et al.
Publicado: (2011)

Optimized S-Trityl-l-cysteine-Based Inhibitors of Kinesin Spindle Protein with Potent in Vivo Antitumor Activity in Lung Cancer Xenograft Models
por: Good, James A. D., et al.
Publicado: (2013)

A New Series of Indeno[1,2-c]pyrazoles as EGFR TK Inhibitors for NSCLC Therapy
por: Özdemir, Ahmet, et al.
Publicado: (2022)

PDI–trityl dyads as photogenerated molecular spin qubit candidates
por: Mayländer, Maximilian, et al.
Publicado: (2023)

EGFR-Targeted Pentacyclic Triterpene Analogues for Glioma Therapy
por: Ciftci, Halil I., et al.
Publicado: (2021)

Anti‐flavivirus Activity of Different Tritylated Pyrimidine and Purine Nucleoside Analogues
por: McGuigan, Christopher, et al.
Publicado: (2016)

Comprehensive Research on Past and Future Therapeutic Strategies Devoted to Treatment of Amyotrophic Lateral Sclerosis
por: Sever, Belgin, et al.
Publicado: (2022)

Thorium–ligand multiple bonds via reductive deprotection of a trityl group
por: Smiles, Danil E., et al.
Publicado: (2015)

SET processes in Lewis acid–base reactions: the tritylation of N-heterocyclic carbenes
por: Dong, Zhaowen, et al.
Publicado: (2020)

Observing Nearby Nuclei on Paramagnetic Trityls and MOFs via DNP and Electron Decoupling
por: Tan, Kong Ooi, et al.
Publicado: (2022)

New Insights into the Structural Requirements of Isatin-Derived Pro-Apoptotic Agents against Acute Myeloid Leukemia
por: Hamdy, Ahmed K., et al.
Publicado: (2022)

In Vitro Cytotoxicity Evaluation of Plastoquinone Analogues against Colorectal and Breast Cancers along with In Silico Insights
por: Ciftci, Halilibrahim, et al.
Publicado: (2022)

Novel Inhibitor for Downstream Targeting of Transforming Growth Factor-β Signaling to Suppress Epithelial to Mesenchymal Transition and Cell Migration
por: Toma, Tsugumasa, et al.
Publicado: (2022)

SUMO pathway, blood coagulation and oxidative stress in SARS-CoV-2 infection
por: Ibrahim, Iman Hassan, et al.
Publicado: (2021)

Methyl 6-O-trityl-α-d-glucopyranoside methanol disolvate
por: Gültekin, Zeynep, et al.
Publicado: (2014)

Qualitative evaluation of regioselectivity in the formation of di- and tri-6-O-tritylates of α-cyclodextrin
por: Yoshikiyo, Keisuke, et al.
Publicado: (2015)

Synthesis and Electrochromism of Highly Organosoluble Polyamides and Polyimides with Bulky Trityl-Substituted Triphenylamine Units
por: Hsiao, Sheng-Huei, et al.
Publicado: (2017)

Excitation Energy Transfer and Exchange‐Mediated Quartet State Formation in Porphyrin‐Trityl Systems
por: Nolden, Oliver, et al.
Publicado: (2020)

Carbocation catalysis in confined space: activation of trityl chloride inside the hexameric resorcinarene capsule
por: De Rosa, Margherita, et al.
Publicado: (2022)

Identification of New L-Heptanoylphosphatidyl Inositol Pentakisphosphate Derivatives Targeting the Interaction with HIV-1 Gag by Molecular Modelling Studies
por: Ciftci, Halilibrahim, et al.
Publicado: (2022)

Studies on 1,4-Quinone Derivatives Exhibiting Anti-Leukemic Activity along with Anti-Colorectal and Anti-Breast Cancer Effects
por: Ciftci, Halilibrahim, et al.
Publicado: (2022)

(S)-Benzyl 3-(4-hydroxyphenyl)-2-(tritylamino)propanoate
por: Chen, Meimei, et al.
Publicado: (2011)

Ox‐SLIM: Synthesis of and Site‐Specific Labelling with a Highly Hydrophilic Trityl Spin Label
por: Fleck, Nico, et al.
Publicado: (2021)

Distance measurement between trityl radicals by pulse dressed electron paramagnetic resonance with phase modulation
por: Wili, Nino, et al.
Publicado: (2020)

Gypsogenin Battling for a Front Position in the Pentacyclic Triterpenes Game of Thrones on Anti-Cancer Therapy: A Critical Review—Dedicated to the Memory of Professor Hanaa M. Rady
por: Radwan, Mohamed O., et al.
Publicado: (2023)

Synthesis of Nanometer Sized Bis- and Tris-trityl Model Compounds with Different Extent of Spin–Spin Coupling
por: Jassoy, J. Jacques, et al.
Publicado: (2018)

Diastereoisomers of l-proline-linked trityl-nitroxide biradicals: synthesis and effect of chiral configurations on exchange interactions
por: Zhai, Weixiang, et al.
Publicado: (2018)

Validation of Plasmodium falciparum dUTPase as the target of 5′-tritylated deoxyuridine analogues with anti-malarial activity
por: Pérez-Moreno, Guiomar, et al.
Publicado: (2019)

PyrroTriPol: a semi-rigid trityl-nitroxide for high field dynamic nuclear polarization
por: Halbritter, Thomas, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_lar1v1f27rfed4go8vq7a2b3im