Multi-Armed 1,2,3-Selenadiazole and 1,2,3-Thiadiazole Benzene Derivatives as Novel Glyoxalase-I Inhibitors

Glyoxalase-I (Glo-I) enzyme was established to be a valid target for anticancer drug design. It performs the essential detoxification step of harmful byproducts, especially methylglyoxal. A robust computer-aided drug design approach was used to design and validate a series of compounds with selenium...

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Detalles Bibliográficos
Autores principales: Al-Balas, Qosay A., Al-Smadi, Mousa L., Hassan, Mohammad A., Al Jabal, Ghazi A., Almaaytah, Ammar M., Alzoubi, Karem H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6766947/
https://www.ncbi.nlm.nih.gov/pubmed/31487813
http://dx.doi.org/10.3390/molecules24183210

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6766947/
https://www.ncbi.nlm.nih.gov/pubmed/31487813
http://dx.doi.org/10.3390/molecules24183210

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