Synthesis and Biological Evaluation of Disubstituted Pyrimidines as Selective 5-HT(2C) Agonists

Here, we describe the synthesis of disubstituted pyrimidine derivatives and their biological evaluation as selective 5-HT(2C) agonists. To improve selectivity for 5-HT(2C) over other subtypes, we synthesized two series of disubstituted pyrimidines with fluorophenylalkoxy groups at either the 5-posit...

Descripción completa

Detalles Bibliográficos
Autores principales: Kim, Juhyeon, Kim, Yoon Jung, Londhe, Ashwini M., Pae, Ae Nim, Choo, Hyunah, Kim, Hak Joong, Min, Sun-Joon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6767204/
https://www.ncbi.nlm.nih.gov/pubmed/31491978
http://dx.doi.org/10.3390/molecules24183234

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6767204/
https://www.ncbi.nlm.nih.gov/pubmed/31491978
http://dx.doi.org/10.3390/molecules24183234

Ejemplares similares