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Synthesis and Biological Evaluation of Disubstituted Pyrimidines as Selective 5-HT(2C) Agonists

Here, we describe the synthesis of disubstituted pyrimidine derivatives and their biological evaluation as selective 5-HT(2C) agonists. To improve selectivity for 5-HT(2C) over other subtypes, we synthesized two series of disubstituted pyrimidines with fluorophenylalkoxy groups at either the 5-posit...

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Detalles Bibliográficos
Autores principales:	Kim, Juhyeon, Kim, Yoon Jung, Londhe, Ashwini M., Pae, Ae Nim, Choo, Hyunah, Kim, Hak Joong, Min, Sun-Joon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6767204/ https://www.ncbi.nlm.nih.gov/pubmed/31491978 http://dx.doi.org/10.3390/molecules24183234

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