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Mechanistic and Structural Insights on the IL-15 System through Molecular Dynamics Simulations
Interleukin 15 (IL-15), a four-helix bundle cytokine, is involved in a plethora of different cellular functions and, particularly, plays a key role in the development and activation of immune responses. IL-15 forms receptor complexes by binding with IL-2Rβ- and common γ (γc)-signaling subunits, whic...
Autores principales: | Sousa, Rui P., Laurent, Adèle D., Quéméner, Agnès, Mortier, Erwan, Le Questel, Jean-Yves |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6767322/ https://www.ncbi.nlm.nih.gov/pubmed/31500206 http://dx.doi.org/10.3390/molecules24183261 |
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