Pharmacokinetic Properties of Ibuprofen (IBU) From the Fixed‐Dose Combination IBU/Caffeine (400/100 mg; FDC) in Comparison With 400 mg IBU as Acid or Lysinate Under Fasted and Fed Conditions—Data From 2 Single‐Center, Single‐Dose, Randomized Crossover Studies in Healthy Volunteers

Rapid onset of analgesic action is linked with rapid absorption of analgesics (high maximum concentration [C(max)] and short time to maximum concentration [t(max)]). After overnight fasting, ibuprofen lysinate reaches higher peak plasma levels (C(max)) earlier than ibuprofen acid (t(max)) with compa...

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Detalles Bibliográficos
Autores principales: Weiser, Thomas, Schepers, Cornelia, Mück, Tobias, Lange, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6767367/
https://www.ncbi.nlm.nih.gov/pubmed/30897305
http://dx.doi.org/10.1002/cpdd.672

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6767367/
https://www.ncbi.nlm.nih.gov/pubmed/30897305
http://dx.doi.org/10.1002/cpdd.672

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