Novel multi-drugs incorporating hybrid-structured nanofibers enhance alkylating agent activity in malignant gliomas

BACKGROUND: Malignant gliomas (MGs) are highly chemotherapy-resistant. Temozolomide (TMZ) and carmustine (BiCNU) are alkylating agents clinically used for treating MGs. However, their effectiveness is restrained by overexpression of the DNA repair protein O(6)-methylguanine-DNA methyltransferase (MG...

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Detalles Bibliográficos
Autores principales: Liu, Shih-Jung, Yang, Shun-Tai, Chen, Shu-Mei, Huang, Yin-Chen, Lee, Wei-Hwa, Ho, Jui, Chen, Yin-Chun, Tseng, Yuan-Yun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2019
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6767748/
https://www.ncbi.nlm.nih.gov/pubmed/31632467
http://dx.doi.org/10.1177/1758835919875555

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6767748/
https://www.ncbi.nlm.nih.gov/pubmed/31632467
http://dx.doi.org/10.1177/1758835919875555

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