Collagen VII Expression Is Required in Both Keratinocytes and Fibroblasts for Anchoring Fibril Formation in Bilayer Engineered Skin Substitutes

The blistering disease recessive dystrophic epidermolysis bullosa (RDEB) is caused by mutations in the gene encoding collagen VII (COL7), which forms anchoring fibrils that attach the epidermis to the dermis. Cutaneous gene therapy to restore COL7 expression in RDEB patient cells has been proposed,...

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Detalles Bibliográficos
Autores principales: Supp, Dorothy M., Hahn, Jennifer M., Combs, Kelly A., McFarland, Kevin L., Schwentker, Ann, Boissy, Raymond E., Boyce, Steven T., Powell, Heather M., Lucky, Anne W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6767893/
https://www.ncbi.nlm.nih.gov/pubmed/31271052
http://dx.doi.org/10.1177/0963689719857657

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6767893/
https://www.ncbi.nlm.nih.gov/pubmed/31271052
http://dx.doi.org/10.1177/0963689719857657

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