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Collagen VII Expression Is Required in Both Keratinocytes and Fibroblasts for Anchoring Fibril Formation in Bilayer Engineered Skin Substitutes
The blistering disease recessive dystrophic epidermolysis bullosa (RDEB) is caused by mutations in the gene encoding collagen VII (COL7), which forms anchoring fibrils that attach the epidermis to the dermis. Cutaneous gene therapy to restore COL7 expression in RDEB patient cells has been proposed,...
Autores principales: | Supp, Dorothy M., Hahn, Jennifer M., Combs, Kelly A., McFarland, Kevin L., Schwentker, Ann, Boissy, Raymond E., Boyce, Steven T., Powell, Heather M., Lucky, Anne W. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6767893/ https://www.ncbi.nlm.nih.gov/pubmed/31271052 http://dx.doi.org/10.1177/0963689719857657 |
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