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(Epi)genomic heterogeneity of pancreatic islet function and failure in type 2 diabetes

BACKGROUND: Pancreatic Islets of Langerhans are heterogeneous tissues consisting of multiple endocrine cell types that carry out distinct yet coordinated roles to regulate blood glucose homeostasis. Islet dysfunction and specifically failure of the beta cells to secrete adequate insulin are known pr...

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Detalles Bibliográficos
Autores principales: Lawlor, Nathan, Stitzel, Michael L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6768501/
https://www.ncbi.nlm.nih.gov/pubmed/31500827
http://dx.doi.org/10.1016/j.molmet.2019.06.002