Regulation of the Notch-ATM-abl axis by geranylgeranyl diphosphate synthase inhibition

Notch proteins drive oncogenesis of many cancers, most prominently T-cell acute lymphoblastic leukemia (T-ALL). Because geranylgeranylated Rab proteins regulate Notch processing, we hypothesized that inhibition of geranylgeranyl diphosphate synthase (GGDPS) would impair Notch processing and reduce v...

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Detalles Bibliográficos
Autores principales: Agabiti, Sherry S., Li, Jin, Dong, Willie, Poe, Michael M., Wiemer, Andrew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6768865/
https://www.ncbi.nlm.nih.gov/pubmed/31570763
http://dx.doi.org/10.1038/s41419-019-1973-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6768865/
https://www.ncbi.nlm.nih.gov/pubmed/31570763
http://dx.doi.org/10.1038/s41419-019-1973-7

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