High levels of AAV vector integration into CRISPR-induced DNA breaks

Adeno-associated virus (AAV) vectors have shown promising results in preclinical models, but the genomic consequences of transduction with AAV vectors encoding CRISPR-Cas nucleases is still being examined. In this study, we observe high levels of AAV integration (up to 47%) into Cas9-induced double-...

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Detalles Bibliográficos
Autores principales: Hanlon, Killian S., Kleinstiver, Benjamin P., Garcia, Sara P., Zaborowski, Mikołaj P., Volak, Adrienn, Spirig, Stefan E., Muller, Alissa, Sousa, Alexander A., Tsai, Shengdar Q., Bengtsson, Niclas E., Lööv, Camilla, Ingelsson, Martin, Chamberlain, Jeffrey S., Corey, David P., Aryee, Martin J., Joung, J. Keith, Breakefield, Xandra O., Maguire, Casey A., György, Bence
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769011/
https://www.ncbi.nlm.nih.gov/pubmed/31570731
http://dx.doi.org/10.1038/s41467-019-12449-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769011/
https://www.ncbi.nlm.nih.gov/pubmed/31570731
http://dx.doi.org/10.1038/s41467-019-12449-2

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