Emerging Alternative Proteinases in APP Metabolism and Alzheimer’s Disease Pathogenesis: A Focus on MT1-MMP and MT5-MMP

Processing of amyloid beta precursor protein (APP) into amyloid-beta peptide (Aβ) by β-secretase and γ-secretase complex is at the heart of the pathogenesis of Alzheimer’s disease (AD). Targeting this proteolytic pathway effectively reduces/prevents pathology and cognitive decline in preclinical exp...

Descripción completa

Detalles Bibliográficos
Autores principales: García-González, Laura, Pilat, Dominika, Baranger, Kévin, Rivera, Santiago
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769103/
https://www.ncbi.nlm.nih.gov/pubmed/31607898
http://dx.doi.org/10.3389/fnagi.2019.00244

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769103/
https://www.ncbi.nlm.nih.gov/pubmed/31607898
http://dx.doi.org/10.3389/fnagi.2019.00244

Ejemplares similares