A consensus set of genetic vulnerabilities to ATR inhibition

The response to DNA replication stress in eukaryotes is under the control of the ataxia–telangiectasia and Rad3-related (ATR) kinase. ATR responds to single-stranded (ss) DNA to stabilize distressed DNA replication forks, modulate DNA replication firing and prevent cells with damaged DNA or incomple...

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Detalles Bibliográficos
Autores principales: Hustedt, Nicole, Álvarez-Quilón, Alejandro, McEwan, Andrea, Yuan, Jing Yi, Cho, Tiffany, Koob, Lisa, Hart, Traver, Durocher, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769295/
https://www.ncbi.nlm.nih.gov/pubmed/31506018
http://dx.doi.org/10.1098/rsob.190156

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769295/
https://www.ncbi.nlm.nih.gov/pubmed/31506018
http://dx.doi.org/10.1098/rsob.190156

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