Allosteric gate modulation confers K(+) coupling in glutamate transporters

Excitatory amino acid transporters (EAATs) mediate glial and neuronal glutamate uptake to terminate synaptic transmission and to ensure low resting glutamate concentrations. Effective glutamate uptake is achieved by cotransport with 3 Na(+) and 1 H(+), in exchange with 1 K(+). The underlying princip...

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Detalles Bibliográficos
Autores principales: Kortzak, Daniel, Alleva, Claudia, Weyand, Ingo, Ewers, David, Zimmermann, Meike I, Franzen, Arne, Machtens, Jan‐Philipp, Fahlke, Christoph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769379/
https://www.ncbi.nlm.nih.gov/pubmed/31506973
http://dx.doi.org/10.15252/embj.2019101468

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769379/
https://www.ncbi.nlm.nih.gov/pubmed/31506973
http://dx.doi.org/10.15252/embj.2019101468

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