Cargando…

In Vitro and In Silico Mechanistic Insights into miR-21-5p-Mediated Topoisomerase Drug Resistance in Human Colorectal Cancer Cells

Although chemotherapy for treating colorectal cancer has had some success, drug resistance and metastasis remain the major causes of death for colorectal cancer patients. MicroRNA-21-5p (hereafter denoted as miR-21) is one of the most abundant miRNAs in human colorectal cancer. A Kaplan–Meier surviv...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Jung-Chien, Hsieh, Yao-Yu, Lo, Hsiang-Ling, Li, Albert, Chou, Chia-Jung, Yang, Pei-Ming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769444/ https://www.ncbi.nlm.nih.gov/pubmed/31505885 http://dx.doi.org/10.3390/biom9090467

Ejemplares similares

miR-21 promotes the fibrotic properties in oral mucosa through targeting PDCD4
por: Liao, Yi-Wen, et al.
Publicado: (2022)

Berberine-targeted miR-21 chemosensitizes oral carcinomas stem cells
por: Lin, Che-Yi, et al.
Publicado: (2017)

New Insights into the Role of miR-29a in Hepatocellular Carcinoma: Implications in Mechanisms and Theragnostics
por: Yang, Ya-Ling, et al.
Publicado: (2021)

Correction: Berberine-targeted miR-21 chemosensitizes oral carcinomas stem cells
por: Lin, Che-Yi, et al.
Publicado: (2018)

An autoregulatory feedback loop of miR-21/VMP1 is responsible for the abnormal expression of miR-21 in colorectal cancer cells
por: Wang, Caixia, et al.
Publicado: (2020)

The Analysis of SNPs’ Function in miR-21 and miR146a/b in Multiple Sclerosis and Active Lesions: An In Silico Study
por: Moraghebi, Mahta, et al.
Publicado: (2022)

Exosomal let-7e, miR-21-5p, miR-145, miR-146a and miR-155 in Predicting Antidepressants Response in Patients with Major Depressive Disorder
por: Hung, Yi-Yung, et al.
Publicado: (2021)

Clinical relevance of microRNA miR-21, miR-31, miR-92a, miR-101, miR-106a and miR-145 in colorectal cancer
por: Schee, Kristina, et al.
Publicado: (2012)

Recent Developments in Combination Chemotherapy for Colorectal and Breast Cancers with Topoisomerase Inhibitors
por: Jang, Jung Yoon, et al.
Publicado: (2023)

Expression and clinical significance of miR-4516 and miR-21-5p in serum of patients with colorectal cancer
por: Jin, Xi-Han, et al.
Publicado: (2020)

Stromal expression of miR-21 in T3-4a colorectal cancer is an independent predictor of early tumor relapse
por: Kang, Won Kyung, et al.
Publicado: (2015)

Mechanistic Insights into the Ameliorative Effect of Cichoriin on Diabetic Rats—Assisted with an In Silico Approach
por: Khalil, Hany Ezzat, et al.
Publicado: (2022)

Mechanistic insights from structure of Mycobacterium smegmatis topoisomerase I with ssDNA bound to both N- and C-terminal domains
por: Cao, Nan, et al.
Publicado: (2020)

Linking Obesity with Colorectal Cancer: Epidemiology and Mechanistic Insights
por: Ye, Pengfei, et al.
Publicado: (2020)

Genetic variant in miR‐21 binding sites is associated with colorectal cancer risk
por: Xie, Lisheng, et al.
Publicado: (2018)

MiR-21-5p Induces Pyroptosis in Colorectal Cancer via TGFBI
por: Jiang, Rilei, et al.
Publicado: (2021)

miR-21 in Human Cardiomyopathies
por: Surina,, et al.
Publicado: (2021)

Structural insights into the gating of DNA passage by the topoisomerase II DNA-gate
por: Chen, Shin-Fu, et al.
Publicado: (2018)

Mechanistic Insight of Bivalent Compound 21MO as Potential Neuroprotectant for Alzheimer’s Disease
por: Saathoff, John M., et al.
Publicado: (2016)

Up-Regulation of miR-21, miR-25, miR-93, and miR-106b in Gastric Cancer
por: Larki, Pegah, et al.
Publicado: (2018)

Inflammation and MiR-21 Pathways Functionally Interact to Downregulate PDCD4 in Colorectal Cancer
por: Peacock, Oliver, et al.
Publicado: (2014)

LINC00312 represses proliferation and metastasis of colorectal cancer cells by regulation of miR‐21
por: Li, Gang, et al.
Publicado: (2018)

Diagnostic role of circulating MiR-21 in colorectal cancer: a update meta-analysis
por: Liu, Tong, et al.
Publicado: (2020)

Mechanistic Insights on Functionalization of Graphene with Ozone
por: Vahdat, Mohammad Tohidi, et al.
Publicado: (2023)

Plasma microRNAs, miR-223, miR-21 and miR-218, as Novel Potential Biomarkers for Gastric Cancer Detection
por: Li, Bo-sheng, et al.
Publicado: (2012)

Artemisinin Derivatives Target Topoisomerase 1 and Cause DNA Damage in Silico and in Vitro
por: Kadioglu, Onat, et al.
Publicado: (2017)

The Role of MicroRNA-21 in Venous Neointimal Hyperplasia: Implications for Targeting miR-21 for VNH Treatment
por: Kilari, Sreenivasulu, et al.
Publicado: (2019)

miR-1246 Targets CCNG2 to Enhance Cancer Stemness and Chemoresistance in Oral Carcinomas
por: Lin, Shih-Shen, et al.
Publicado: (2018)

MiR-424/TGIF2-Mediated Pro-Fibrogenic Responses in Oral Submucous Fibrosis
por: Chou, Ming-Yung, et al.
Publicado: (2023)

Snail-overexpressing Cancer Cells Promote M2-Like Polarization of Tumor-Associated Macrophages by Delivering MiR-21-Abundant Exosomes
por: Hsieh, Chia-Hsin, et al.
Publicado: (2018)

Potential role of plasma miR-21 and miR-92a in distinguishing between irritable bowel syndrome, ulcerative colitis, and colorectal cancer
por: Ahmed Hassan, Elham, et al.
Publicado: (2020)

MiR-21 Expression in Wilms’ Tumor
por: Bazzaz, Navid, et al.
Publicado: (2018)

Corrigendum: miR-21 in Human Cardiomyopathies
por: Surina,, et al.
Publicado: (2022)

miR-16 and miR-21 Expression in the Placenta Is Associated with Fetal Growth
por: Maccani, Matthew A., et al.
Publicado: (2011)

miR-15b and miR-21 as Circulating Biomarkers for Diagnosis of Glioma
por: Ivo D’Urso, Pietro, et al.
Publicado: (2015)

Expression and predictive value of miR-489 and miR-21 in melanoma metastasis
por: Mo, Hao, et al.
Publicado: (2019)

Biomarker significance of plasma and tumor miR-21, miR-221, and miR-106a in osteosarcoma
por: Nakka, Manjula, et al.
Publicado: (2017)

Association of miR-21, miR-126 and miR-605 gene polymorphisms with ischemic stroke risk
por: Xiang, Yang, et al.
Publicado: (2017)

Mechanistic insights into zearalenone-accelerated colorectal cancer in mice using integrative multi-omics approaches
por: Lo, Emily Kwun Kwan, et al.
Publicado: (2023)

A comprehensive review on miR-153: Mechanistic and controversial roles of miR-153 in tumorigenicity of cancer cells
por: Yousefnia, Saghar
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_1iotfbu7a2i95o07jv831af4ma