Polymorphisms of CYP2C8 Alter First-Electron Transfer Kinetics and Increase Catalytic Uncoupling

Cytochrome P450 2C8 (CYP2C8) epoxygenase is responsible for the metabolism of over 60 clinically relevant drugs, notably the anticancer drug Taxol (paclitaxel, PAC). Specifically, there are naturally occurring polymorphisms, CYP2C8*2 and CYP2C8*3, that display altered PAC hydroxylation rates despite...

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Detalles Bibliográficos
Autores principales: R. Arnold, William, Zelasko, Susan, D. Meling, Daryl, Sam, Kimberly, Das, Aditi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769586/
https://www.ncbi.nlm.nih.gov/pubmed/31540428
http://dx.doi.org/10.3390/ijms20184626

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769586/
https://www.ncbi.nlm.nih.gov/pubmed/31540428
http://dx.doi.org/10.3390/ijms20184626

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