The Anti-Amyloidogenic Action of Doxycycline: A Molecular Dynamics Study on the Interaction with Aβ42

The pathological aggregation of amyloidogenic proteins is a hallmark of many neurological diseases, including Alzheimer’s disease and prion diseases. We have shown both in vitro and in vivo that doxycycline can inhibit the aggregation of Aβ42 amyloid fibrils and disassemble mature amyloid fibrils. H...

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Detalles Bibliográficos
Autores principales: Gautieri, Alfonso, Beeg, Marten, Gobbi, Marco, Rigoldi, Federica, Colombo, Laura, Salmona, Mario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769662/
https://www.ncbi.nlm.nih.gov/pubmed/31546787
http://dx.doi.org/10.3390/ijms20184641

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769662/
https://www.ncbi.nlm.nih.gov/pubmed/31546787
http://dx.doi.org/10.3390/ijms20184641

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