Mechanism of Action of the Tumor Vessel Targeting Agent NGR-hTNF: Role of Both NGR Peptide and hTNF in Cell Binding and Signaling

NGR-hTNF is a therapeutic agent for a solid tumor that specifically targets angiogenic tumor blood vessels, through the NGR motif. Its activity has been assessed in several clinical studies encompassing tumors of different histological types. The drug’s activity is based on an improved permeabilizat...

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Detalles Bibliográficos
Autores principales: Valentinis, Barbara, Porcellini, Simona, Asperti, Claudia, Cota, Manuela, Zhou, Dan, Di Matteo, Paola, Garau, Gianpiero, Zucchelli, Chiara, Avanzi, Nilla Roberta, Rizzardi, Gian Paolo, Degano, Massimo, Musco, Giovanna, Traversari, Catia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769691/
https://www.ncbi.nlm.nih.gov/pubmed/31547231
http://dx.doi.org/10.3390/ijms20184511

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769691/
https://www.ncbi.nlm.nih.gov/pubmed/31547231
http://dx.doi.org/10.3390/ijms20184511

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