Allosteric AKT Inhibitors Target Synthetic Lethal Vulnerabilities in E-Cadherin-Deficient Cells

The CDH1 gene, encoding the cell adhesion protein E-cadherin, is one of the most frequently mutated genes in gastric cancer and inactivating germline CDH1 mutations are responsible for hereditary diffuse gastric cancer syndrome (HDGC). Using cell viability assays, we identified that breast (MCF10A)...

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Detalles Bibliográficos
Autores principales: Bougen-Zhukov, Nicola, Nouri, Yasmin, Godwin, Tanis, Taylor, Megan, Hakkaart, Christopher, Single, Andrew, Brew, Tom, Permina, Elizabeth, Chen, Augustine, Black, Michael A., Guilford, Parry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769709/
https://www.ncbi.nlm.nih.gov/pubmed/31540244
http://dx.doi.org/10.3390/cancers11091359

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769709/
https://www.ncbi.nlm.nih.gov/pubmed/31540244
http://dx.doi.org/10.3390/cancers11091359

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