Blockade of PD-L1 Enhances Cancer Immunotherapy by Regulating Dendritic Cell Maturation and Macrophage Polarization

The immuno-inhibitory checkpoint PD-L1, regulated by tumor cells and antigen-presenting cells (APCs), dampened the activation of T cells from the PD-1/PD-L1 axis. PD-L1-expressing APCs rather than tumor cells demonstrated the essential anti-tumor effects of anti-PD-L1 monotherapy in preclinical tumo...

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Detalles Bibliográficos
Autores principales: Sun, Nai-Yun, Chen, Yu-Li, Wu, Wen-Yih, Lin, Han-Wei, Chiang, Ying-Cheng, Chang, Chi-Fang, Tai, Yi-Jou, Hsu, Heng-Cheng, Chen, Chi-An, Sun, Wei-Zen, Cheng, Wen-Fang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769724/
https://www.ncbi.nlm.nih.gov/pubmed/31546897
http://dx.doi.org/10.3390/cancers11091400

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769724/
https://www.ncbi.nlm.nih.gov/pubmed/31546897
http://dx.doi.org/10.3390/cancers11091400

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