Xanthohumol, a Prenylated Flavonoid from Hops, Induces Caspase-Dependent Degradation of Oncoprotein BCR-ABL in K562 Cells

BCR-ABL oncoprotein drives the initiation, promotion, and progression of chronic myelogenous leukemia (CML). Tyrosine kinase inhibitors are the first choice for CML therapy, however, BCR-ABL mediated drug resistance limits its clinical application and prognosis. A novel promising therapeutic strateg...

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Detalles Bibliográficos
Autores principales: Lu, Xuxiu, Geng, Jiajia, Zhang, Jinman, Miao, Jinlai, Liu, Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769755/
https://www.ncbi.nlm.nih.gov/pubmed/31527518
http://dx.doi.org/10.3390/antiox8090402

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769755/
https://www.ncbi.nlm.nih.gov/pubmed/31527518
http://dx.doi.org/10.3390/antiox8090402

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