The Phosphatase SHP-2 Activates HIF-1α in Wounds In Vivo by Inhibition of 26S Proteasome Activity

Vascular remodeling and angiogenesis are required to improve the perfusion of ischemic tissues. The hypoxic environment, induced by ischemia, is a potent stimulus for hypoxia inducible factor 1α (HIF-1α) upregulation and activation, which induce pro-angiogenic gene expression. We previously showed t...

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Detalles Bibliográficos
Autores principales: Heun, Yvonn, Grundler Groterhorst, Katharina, Pogoda, Kristin, Kraemer, Bjoern F, Pfeifer, Alexander, Pohl, Ulrich, Mannell, Hanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769879/
https://www.ncbi.nlm.nih.gov/pubmed/31500245
http://dx.doi.org/10.3390/ijms20184404

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769879/
https://www.ncbi.nlm.nih.gov/pubmed/31500245
http://dx.doi.org/10.3390/ijms20184404

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