Oxidation of Human Copper Chaperone Atox1 and Disulfide Bond Cleavage by Cisplatin and Glutathione

Cancer cells cope with high oxidative stress levels, characterized by a shift toward the oxidized form (GSSG) of glutathione (GSH) in the redox couple GSSG/2GSH. Under these conditions, the cytosolic copper chaperone Atox1, which delivers Cu(I) to the secretory pathway, gets oxidized, i.e., a disulf...

Descripción completa

Detalles Bibliográficos
Autores principales: Nardella, Maria I., Rosato, Antonio, Belviso, Benny D., Caliandro, Rocco, Natile, Giovanni, Arnesano, Fabio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769983/
https://www.ncbi.nlm.nih.gov/pubmed/31500118
http://dx.doi.org/10.3390/ijms20184390

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769983/
https://www.ncbi.nlm.nih.gov/pubmed/31500118
http://dx.doi.org/10.3390/ijms20184390

Ejemplares similares