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Oxidation of Human Copper Chaperone Atox1 and Disulfide Bond Cleavage by Cisplatin and Glutathione

Cancer cells cope with high oxidative stress levels, characterized by a shift toward the oxidized form (GSSG) of glutathione (GSH) in the redox couple GSSG/2GSH. Under these conditions, the cytosolic copper chaperone Atox1, which delivers Cu(I) to the secretory pathway, gets oxidized, i.e., a disulf...

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Detalles Bibliográficos
Autores principales:	Nardella, Maria I., Rosato, Antonio, Belviso, Benny D., Caliandro, Rocco, Natile, Giovanni, Arnesano, Fabio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769983/ https://www.ncbi.nlm.nih.gov/pubmed/31500118 http://dx.doi.org/10.3390/ijms20184390

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