Novel Heat Shock Protein 90 Inhibitors Suppress P-Glycoprotein Activity and Overcome Multidrug Resistance in Cancer Cells

Heat Shock Protein 90 (Hsp90) chaperone interacts with a broad range of client proteins involved in cancerogenesis and cancer progression. However, Hsp90 inhibitors were unsuccessful as anticancer agents due to their high toxicity, lack of selectivity against cancer cells and extrusion by membrane t...

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Detalles Bibliográficos
Autores principales: Dinić, Jelena, Podolski-Renić, Ana, Jovanović, Mirna, Musso, Loana, Tsakovska, Ivanka, Pajeva, Ilza, Dallavalle, Sabrina, Pešić, Milica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770006/
https://www.ncbi.nlm.nih.gov/pubmed/31527404
http://dx.doi.org/10.3390/ijms20184575

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770006/
https://www.ncbi.nlm.nih.gov/pubmed/31527404
http://dx.doi.org/10.3390/ijms20184575

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