Carbidopa Alters Tryptophan Metabolism in Breast Cancer and Melanoma Cells Leading to the Formation of Indole-3-Acetonitrile, a Pro-Proliferative Metabolite

Carbidopa is used for the treatment of Parkinson’s disease (PD) as an inhibitor of DOPA decarboxylase, and PD patients taking carbidopa have a lower incidence of various tumors, except for breast cancer and melanoma. Recently, it was shown that carbidopa inhibits tryptophan-2,3-dioxygenase (TDO) and...

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Detalles Bibliográficos
Autores principales: Duarte, Diana, Amaro, Filipa, Silva, Isabel, Silva, Dany, Fresco, Paula, Oliveira, José C., Reguengo, Henrique, Gonçalves, Jorge, Vale, Nuno
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770008/
https://www.ncbi.nlm.nih.gov/pubmed/31450593
http://dx.doi.org/10.3390/biom9090409

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770008/
https://www.ncbi.nlm.nih.gov/pubmed/31450593
http://dx.doi.org/10.3390/biom9090409

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