FMK, an Inhibitor of p90RSK, Inhibits High Glucose-Induced TXNIP Expression via Regulation of ChREBP in Pancreatic β Cells

Hyperglycemia is the major characteristic of diabetes mellitus, and a chronically high glucose (HG) level causes β-cell glucolipotoxicity, which is characterized by lipid accumulation, impaired β-cell function, and apoptosis. TXNIP (Thioredoxin-interacting protein) is a key mediator of diabetic β-ce...

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Detalles Bibliográficos
Autores principales: Han, Jung-Hwa, Kim, Suji, Kim, Sujin, Lee, Heejung, Park, So-Young, Woo, Chang-Hoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770409/
https://www.ncbi.nlm.nih.gov/pubmed/31505737
http://dx.doi.org/10.3390/ijms20184424

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770409/
https://www.ncbi.nlm.nih.gov/pubmed/31505737
http://dx.doi.org/10.3390/ijms20184424

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