Human DNA Telomeres in Presence of Oxidative Lesions: The Crucial Role of Electrostatic Interactions on the Stability of Guanine Quadruplexes

By using all atom molecular dynamics simulations, we studied the behavior of human DNA telomere sequences in guanine quadruplex (G4) conformation and in the presence of oxidative lesions, namely abasic sites. In particular, we evidenced that while removing one guanine base induces a significant alte...

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Detalles Bibliográficos
Autores principales: Hognon, Cecilia, Gebus, Adrien, Barone, Giampaolo, Monari, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770428/
https://www.ncbi.nlm.nih.gov/pubmed/31443537
http://dx.doi.org/10.3390/antiox8090337

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770428/
https://www.ncbi.nlm.nih.gov/pubmed/31443537
http://dx.doi.org/10.3390/antiox8090337

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