IDE Degrades Nociceptin/Orphanin FQ through an Insulin Regulated Mechanism

Insulin-degrading enzyme (IDE) was applied to catalyze hydrolysis of Nociceptin/Orphanin 1-16 (OFQ/N) to show the involvement of the enzyme in degradation of neuropeptides engaged in pain transmission. Moreover, IDE degradative action towards insulin (Ins) was inhibited by the OFQ/N fragments, sugge...

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Detalles Bibliográficos
Autores principales: Zingale, Gabriele Antonio, Bellia, Francesco, Ahmed, Ikhlas Mohamed Mohamud, Mielczarek, Przemyslaw, Silberring, Jerzy, Grasso, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770469/
https://www.ncbi.nlm.nih.gov/pubmed/31509943
http://dx.doi.org/10.3390/ijms20184447

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770469/
https://www.ncbi.nlm.nih.gov/pubmed/31509943
http://dx.doi.org/10.3390/ijms20184447

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