For Better or Worse: The Potential for Dose Limiting the On-Target Toxicity of PI 3-Kinase Inhibitors

The hyper-activation of the phosphoinositide (PI) 3-kinase signaling pathway is a hallmark of many cancers and overgrowth syndromes, and as a result, there has been intense interest in the development of drugs that target the various isoforms of PI 3-kinase. Given the key role PI 3-kinases play in m...

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Detalles Bibliográficos
Autores principales: Buchanan, Christina M., Lee, Kate L., Shepherd, Peter R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770514/
https://www.ncbi.nlm.nih.gov/pubmed/31443495
http://dx.doi.org/10.3390/biom9090402

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770514/
https://www.ncbi.nlm.nih.gov/pubmed/31443495
http://dx.doi.org/10.3390/biom9090402

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