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The Link of the Prion Protein with Ca(2+) Metabolism and ROS Production, and the Possible Implication in Aβ Toxicity
The cellular prion protein (PrP(C)) is an ubiquitous cell surface protein mostly expressed in neurons, where it localizes to both pre- and post-synaptic membranes. PrP(C) aberrant conformers are the major components of mammalian prions, the infectious agents responsible for incurable neurodegenerati...
Autores principales: | De Mario, Agnese, Peggion, Caterina, Massimino, Maria Lina, Norante, Rosa Pia, Zulian, Alessandra, Bertoli, Alessandro, Sorgato, Maria Catia |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770541/ https://www.ncbi.nlm.nih.gov/pubmed/31546771 http://dx.doi.org/10.3390/ijms20184640 |
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