Differing Membrane Interactions of Two Highly Similar Drug-Metabolizing Cytochrome P450 Isoforms: CYP 2C9 and CYP 2C19

The human cytochrome P450 (CYP) 2C9 and 2C19 enzymes are two highly similar isoforms with key roles in drug metabolism. They are anchored to the endoplasmic reticulum membrane by their N-terminal transmembrane helix and interactions of their cytoplasmic globular domain with the membrane. However, th...

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Detalles Bibliográficos
Autores principales: Mustafa, Ghulam, Nandekar, Prajwal P., Bruce, Neil J., Wade, Rebecca C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770661/
https://www.ncbi.nlm.nih.gov/pubmed/31487853
http://dx.doi.org/10.3390/ijms20184328

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770661/
https://www.ncbi.nlm.nih.gov/pubmed/31487853
http://dx.doi.org/10.3390/ijms20184328

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