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Regulation of I(Ks) Potassium Current by Isoproterenol in Adult Cardiomyocytes Requires Type 9 Adenylyl Cyclase

The subunits KCNQ1 and KCNE1 generate the slowly activating, delayed rectifier potassium current, I(Ks), that responds to sympathetic stimulation and is critical for human cardiac repolarization. The A-kinase anchoring protein Yotiao facilitates macromolecular complex formation between I(Ks) and pro...

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Detalles Bibliográficos
Autores principales: Li, Yong, Hof, Thomas, Baldwin, Tanya A., Chen, Lei, Kass, Robert S., Dessauer, Carmen W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770663/
https://www.ncbi.nlm.nih.gov/pubmed/31461851
http://dx.doi.org/10.3390/cells8090981