CRISPR/Cas9 Editing of the Polyomavirus Tumor Antigens Inhibits Merkel Cell Carcinoma Growth In Vitro

Merkel cell carcinoma (MCC) is an aggressive type of skin cancer whose main causative agent is Merkel cell polyomavirus (MCPyV). MCPyV is integrated into the genome of the tumor cells in most MCCs. Virus-positive tumor cells constitutively express two viral oncoproteins that promote cell growth: the...

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Detalles Bibliográficos
Autores principales: Temblador, Arturo, Topalis, Dimitrios, Andrei, Graciela, Snoeck, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770690/
https://www.ncbi.nlm.nih.gov/pubmed/31466237
http://dx.doi.org/10.3390/cancers11091260

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770690/
https://www.ncbi.nlm.nih.gov/pubmed/31466237
http://dx.doi.org/10.3390/cancers11091260

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