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Somatic Mutations of lats2 Cause Peripheral Nerve Sheath Tumors in Zebrafish
The cellular signaling pathways underlying peripheral nerve sheath tumor (PNST) formation are poorly understood. Hippo signaling has been recently implicated in the biology of various cancers, and is thought to function downstream of mutations in the known PNST driver, NF2. Utilizing CRISPR-Cas9 gen...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770745/ https://www.ncbi.nlm.nih.gov/pubmed/31450674 http://dx.doi.org/10.3390/cells8090972 |