Somatic Mutations of lats2 Cause Peripheral Nerve Sheath Tumors in Zebrafish

The cellular signaling pathways underlying peripheral nerve sheath tumor (PNST) formation are poorly understood. Hippo signaling has been recently implicated in the biology of various cancers, and is thought to function downstream of mutations in the known PNST driver, NF2. Utilizing CRISPR-Cas9 gen...

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Detalles Bibliográficos
Autores principales: Brandt, Zachary J., North, Paula N., Link, Brian A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770745/
https://www.ncbi.nlm.nih.gov/pubmed/31450674
http://dx.doi.org/10.3390/cells8090972

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