Inhibition of Mitochondrial Complex I Impairs Release of α-Galactosidase by Jurkat Cells

Fabry disease (FD) is caused by mutations in the GLA gene that encodes lysosomal α-galactosidase-A (α-gal-A). A number of pathogenic mechanisms have been proposed and these include loss of mitochondrial respiratory chain activity. For FD, gene therapy is beginning to be applied as a treatment. In vi...

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Detalles Bibliográficos
Autores principales: Lambert, Jonathan R. A., Howe, Steven J., Rahim, Ahad A., Burke, Derek G., Heales, Simon J. R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770804/
https://www.ncbi.nlm.nih.gov/pubmed/31491876
http://dx.doi.org/10.3390/ijms20184349

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770804/
https://www.ncbi.nlm.nih.gov/pubmed/31491876
http://dx.doi.org/10.3390/ijms20184349

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