Cargando…
Inhibition of Mitochondrial Complex I Impairs Release of α-Galactosidase by Jurkat Cells
Fabry disease (FD) is caused by mutations in the GLA gene that encodes lysosomal α-galactosidase-A (α-gal-A). A number of pathogenic mechanisms have been proposed and these include loss of mitochondrial respiratory chain activity. For FD, gene therapy is beginning to be applied as a treatment. In vi...
| Autores principales: | , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2019
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770804/ https://www.ncbi.nlm.nih.gov/pubmed/31491876 http://dx.doi.org/10.3390/ijms20184349 |