Anti-Tumor Potential of IMP Dehydrogenase Inhibitors: A Century-Long Story

The purine nucleotides ATP and GTP are essential precursors to DNA and RNA synthesis and fundamental for energy metabolism. Although de novo purine nucleotide biosynthesis is increased in highly proliferating cells, such as malignant tumors, it is not clear if this is merely a secondary manifestatio...

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Detalles Bibliográficos
Autores principales: Naffouje, Rand, Grover, Punita, Yu, Hongyang, Sendilnathan, Arun, Wolfe, Kara, Majd, Nazanin, Smith, Eric P., Takeuchi, Koh, Senda, Toshiya, Kofuji, Satoshi, Sasaki, Atsuo T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770829/
https://www.ncbi.nlm.nih.gov/pubmed/31514446
http://dx.doi.org/10.3390/cancers11091346

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770829/
https://www.ncbi.nlm.nih.gov/pubmed/31514446
http://dx.doi.org/10.3390/cancers11091346

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