Emerging Role of USP8, HMGA, and Non-Coding RNAs in Pituitary Tumorigenesis

Two novel molecular mechanisms with a driver role in pituitary tumorigenesis have been recently identified. They are (a) mutations in the Ubiquitin-Specific Protease 8 (USP8) gene in corticotroph tumors and (b) overexpression of the HMGA1 and HMGA2 genes in most of the pituitary tumors. Moreover, de...

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Autores principales: D’Angelo, Daniela, De Martino, Marco, Arra, Claudio, Fusco, Alfredo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770943/
https://www.ncbi.nlm.nih.gov/pubmed/31487906
http://dx.doi.org/10.3390/cancers11091302
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author D’Angelo, Daniela
De Martino, Marco
Arra, Claudio
Fusco, Alfredo
author_facet D’Angelo, Daniela
De Martino, Marco
Arra, Claudio
Fusco, Alfredo
author_sort D’Angelo, Daniela
collection PubMed
description Two novel molecular mechanisms with a driver role in pituitary tumorigenesis have been recently identified. They are (a) mutations in the Ubiquitin-Specific Protease 8 (USP8) gene in corticotroph tumors and (b) overexpression of the HMGA1 and HMGA2 genes in most of the pituitary tumors. Moreover, deregulated expression of the non-coding RNAs has been very frequently observed in this neoplasia. The aim of this review is to better elucidate the role, the mechanisms, and the possible clinical impact of these novel alterations in the development of pituitary neoplasia.
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spelling pubmed-67709432019-10-30 Emerging Role of USP8, HMGA, and Non-Coding RNAs in Pituitary Tumorigenesis D’Angelo, Daniela De Martino, Marco Arra, Claudio Fusco, Alfredo Cancers (Basel) Review Two novel molecular mechanisms with a driver role in pituitary tumorigenesis have been recently identified. They are (a) mutations in the Ubiquitin-Specific Protease 8 (USP8) gene in corticotroph tumors and (b) overexpression of the HMGA1 and HMGA2 genes in most of the pituitary tumors. Moreover, deregulated expression of the non-coding RNAs has been very frequently observed in this neoplasia. The aim of this review is to better elucidate the role, the mechanisms, and the possible clinical impact of these novel alterations in the development of pituitary neoplasia. MDPI 2019-09-04 /pmc/articles/PMC6770943/ /pubmed/31487906 http://dx.doi.org/10.3390/cancers11091302 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
D’Angelo, Daniela
De Martino, Marco
Arra, Claudio
Fusco, Alfredo
Emerging Role of USP8, HMGA, and Non-Coding RNAs in Pituitary Tumorigenesis
title Emerging Role of USP8, HMGA, and Non-Coding RNAs in Pituitary Tumorigenesis
title_full Emerging Role of USP8, HMGA, and Non-Coding RNAs in Pituitary Tumorigenesis
title_fullStr Emerging Role of USP8, HMGA, and Non-Coding RNAs in Pituitary Tumorigenesis
title_full_unstemmed Emerging Role of USP8, HMGA, and Non-Coding RNAs in Pituitary Tumorigenesis
title_short Emerging Role of USP8, HMGA, and Non-Coding RNAs in Pituitary Tumorigenesis
title_sort emerging role of usp8, hmga, and non-coding rnas in pituitary tumorigenesis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770943/
https://www.ncbi.nlm.nih.gov/pubmed/31487906
http://dx.doi.org/10.3390/cancers11091302
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