Quinacrine-Mediated Inhibition of Nrf2 Reverses Hypoxia-Induced 5-Fluorouracil Resistance in Colorectal Cancer

5-Fluorouracil (5-FU) is an important chemotherapeutic agent for the systemic treatment of colorectal cancer (CRC), but its effectiveness against CRC is limited by increased 5-FU resistance caused by the hypoxic tumor microenvironment. The purpose of our study was to assess the feasibility of using...

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Detalles Bibliográficos
Autores principales: Kim, Ha Gyeong, Kim, Chan Woo, Lee, Don Haeng, Lee, Jae-Seon, Oh, Eun-Taex, Park, Heon Joo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770959/
https://www.ncbi.nlm.nih.gov/pubmed/31491980
http://dx.doi.org/10.3390/ijms20184366

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770959/
https://www.ncbi.nlm.nih.gov/pubmed/31491980
http://dx.doi.org/10.3390/ijms20184366

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