BRCA2 Deletion Induces Alternative Lengthening of Telomeres in Telomerase Positive Colon Cancer Cells

BRCA1/2 are tumor suppressor genes controlling genomic stability also at telomeric and subtelomeric loci. Their mutation confers a predisposition to different human cancers but also sensitivity to antitumor drugs including poly(ADP-ribose) polymerase (PARP) inhibitors and G-quadruplex stabilizers. H...

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Detalles Bibliográficos
Autores principales: Pompili, Luca, Maresca, Carmen, Dello Stritto, Angela, Biroccio, Annamaria, Salvati, Erica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6771010/
https://www.ncbi.nlm.nih.gov/pubmed/31510074
http://dx.doi.org/10.3390/genes10090697

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6771010/
https://www.ncbi.nlm.nih.gov/pubmed/31510074
http://dx.doi.org/10.3390/genes10090697

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