Automethylation of PRC2 promotes H3K27 methylation and is impaired in H3K27M pediatric glioma

The histone methyltransferase activity of PRC2 is central to the formation of H3K27me3-decorated facultative heterochromatin and gene silencing. In addition, PRC2 has been shown to automethylate its core subunits, EZH1/EZH2 and SUZ12. Here, we identify the lysine residues at which EZH1/EZH2 are auto...

Descripción completa

Detalles Bibliográficos
Autores principales: Lee, Chul-Hwan, Yu, Jia-Ray, Granat, Jeffrey, Saldaña-Meyer, Ricardo, Andrade, Joshua, LeRoy, Gary, Jin, Ying, Lund, Peder, Stafford, James M., Garcia, Benjamin A., Ueberheide, Beatrix, Reinberg, Danny
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6771381/
https://www.ncbi.nlm.nih.gov/pubmed/31488577
http://dx.doi.org/10.1101/gad.328773.119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6771381/
https://www.ncbi.nlm.nih.gov/pubmed/31488577
http://dx.doi.org/10.1101/gad.328773.119

Ejemplares similares