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Automethylation of PRC2 promotes H3K27 methylation and is impaired in H3K27M pediatric glioma
The histone methyltransferase activity of PRC2 is central to the formation of H3K27me3-decorated facultative heterochromatin and gene silencing. In addition, PRC2 has been shown to automethylate its core subunits, EZH1/EZH2 and SUZ12. Here, we identify the lysine residues at which EZH1/EZH2 are auto...
Autores principales: | Lee, Chul-Hwan, Yu, Jia-Ray, Granat, Jeffrey, Saldaña-Meyer, Ricardo, Andrade, Joshua, LeRoy, Gary, Jin, Ying, Lund, Peder, Stafford, James M., Garcia, Benjamin A., Ueberheide, Beatrix, Reinberg, Danny |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory Press
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6771381/ https://www.ncbi.nlm.nih.gov/pubmed/31488577 http://dx.doi.org/10.1101/gad.328773.119 |
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