Inverting Small Molecule–Protein Recognition by the Fluorine Gauche Effect: Selectivity Regulated by Multiple H→F Bioisosterism

Fluorinated motifs have a venerable history in drug discovery, but as C(sp(3))−F‐rich 3D scaffolds appear with increasing frequency, the effect of multiple bioisosteric changes on molecular recognition requires elucidation. Herein we demonstrate that installation of a 1,3,5‐stereotriad, in the subst...

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Detalles Bibliográficos
Autores principales: Bentler, Patrick, Bergander, Klaus, Daniliuc, Constantin G., Mück‐Lichtenfeld, Christian, Jumde, Ravindra P., Hirsch, Anna K. H., Gilmour, Ryan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6771710/
https://www.ncbi.nlm.nih.gov/pubmed/31157945
http://dx.doi.org/10.1002/anie.201905452

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6771710/
https://www.ncbi.nlm.nih.gov/pubmed/31157945
http://dx.doi.org/10.1002/anie.201905452

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