The aspartimide problem persists: Fluorenylmethyloxycarbonyl‐solid‐phase peptide synthesis (Fmoc‐SPPS) chain termination due to formation of N‐terminal piperazine‐2,5‐diones

Aspartimide (Asi) formation is a notorious side reaction in peptide synthesis that is well characterized and described in literature. In this context, we observed significant amounts of chain termination in Fmoc‐SPPS while synthesizing the N‐terminal Xaa‐Asp‐Yaa motif. This termination was caused by...

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Detalles Bibliográficos
Autores principales: Samson, Daniel, Rentsch, Daniel, Minuth, Marco, Meier, Thomas, Loidl, Günther
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6772008/
https://www.ncbi.nlm.nih.gov/pubmed/31309675
http://dx.doi.org/10.1002/psc.3193

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6772008/
https://www.ncbi.nlm.nih.gov/pubmed/31309675
http://dx.doi.org/10.1002/psc.3193

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