Combinatorial mutagenesis of rapidly evolving residues yields super-restrictor antiviral proteins

Antagonistic interactions drive host–virus evolutionary arms races, which often manifest as recurrent amino acid changes (i.e., positive selection) at their protein–protein interaction interfaces. Here, we investigated whether combinatorial mutagenesis of positions under positive selection in a host...

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Detalles Bibliográficos
Autores principales: Colón-Thillet, Rossana, Hsieh, Emily, Graf, Laura, McLaughlin, Richard N., Young, Janet M., Kochs, Georg, Emerman, Michael, Malik, Harmit S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6772013/
https://www.ncbi.nlm.nih.gov/pubmed/31574080
http://dx.doi.org/10.1371/journal.pbio.3000181

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6772013/
https://www.ncbi.nlm.nih.gov/pubmed/31574080
http://dx.doi.org/10.1371/journal.pbio.3000181

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