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Combinatorial mutagenesis of rapidly evolving residues yields super-restrictor antiviral proteins
Antagonistic interactions drive host–virus evolutionary arms races, which often manifest as recurrent amino acid changes (i.e., positive selection) at their protein–protein interaction interfaces. Here, we investigated whether combinatorial mutagenesis of positions under positive selection in a host...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6772013/ https://www.ncbi.nlm.nih.gov/pubmed/31574080 http://dx.doi.org/10.1371/journal.pbio.3000181 |