KRAS Binders Hidden in Nature

Natural products have proven to be a rich source of molecular architectures for drugs. Here, an integrated approach to natural product screening is proposed, which uncovered eight new natural product scaffolds for KRAS—the most frequently mutated oncogenic driver in human cancers, which has remained...

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Detalles Bibliográficos
Autores principales: Bergner, Andreas, Cockcroft, Xiaoling, Fischer, Gerhard, Gollner, Andreas, Hela, Wolfgang, Kousek, Roland, Mantoulidis, Andreas, Martin, Laetitia J., Mayer, Moriz, Müllauer, Barbara, Siszler, Gabriella, Wolkerstorfer, Bernhard, Kessler, Dirk, McConnell, Darryl B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6772028/
https://www.ncbi.nlm.nih.gov/pubmed/31231840
http://dx.doi.org/10.1002/chem.201902810

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6772028/
https://www.ncbi.nlm.nih.gov/pubmed/31231840
http://dx.doi.org/10.1002/chem.201902810

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